Kako se skriva povzročitelj tuberkuloze
Image via WikipediaVstop v makrofage in izogibanje intracelularnim uničevalnim mehanizmom, vključno z fagosomsko-lizosomsko funkcijo, so ključni elementi patogeneze M. tuberculosis (bakterija, ki povzroča tuberkulozo).
Raziskovalci so identificirali protein s fukcijo tirozinske kinaze, ki ga M. tuberculosis izloča in s tem verjetno vpliva na signalne poti.
Blokiranje tega proteina oslabi rast TBC v človeških makrofagih. Očitno lahko pričakujemo biološka zdravila tudi za zdravljenje tuberkuloze. (Povzetek na pubmedu: Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B.)
Raziskovalci na Univerzi British Columbia in na Coastal Health Research Institute iz Vancouvra so odkrili, kako se bakterije tuberkuloze skrivajo in razmnožujejo v človeškem telesu.
Vir: MIKROB(io)LOG: Kako se skriva povzročitelj tuberkuloze
Statistika TBC:
TB is called the ultimate killer. It is the leading cause of death among infectious diseases in the world today and is responsible for one in four adult preventable deaths, according to the World Health Organization (WHO). Ten million new cases of TB arise every year, killing close to two million people worldwide annually. Every 20 seconds TB kills someone and approximately 4,400 people die every day. The WHO estimates that one-third of the world’s population is infected. The current treatment regime involves taking multiple medications over an extended period of time.
Vir: How Tuberculosis Bacteria Hide And Multiply In The Human Body
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1 Novo cepivo za tuberkolozo na testiranju // Sep 13, 2008 at 10:16 am
[...] članku Kako se skriva povzročitel TBC, objavljam še novico o testiranju novega cepiva za tuberkulozo. A clinical trial has begun on a [...]
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